Detection method of trimethylacetic acid in ampicillin and/or ampicillin sodium

• Main Authors: MA HUILING, LYU QINGHUI, CHEN LILI
• Format: Patent
• Language: Chinese; English
• Published: 19.03.2019
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The invention discloses a detection method of remaining trimethylacetic acid in ampicillin and/or ampicillin sodium. A sample to be detected is detected by a gas chromatographic method, nature or quantity is determined according to chromatographic results, chromatographic conditions include that a chromatographic column is a capillary chromatographic column taking nitroterephthalic acid modified polyethylene glycol as stationary liquid or a chromatographic column with similar or same polarity, a detector is an FID (flame ionization detector), column temperature increase procedures include thatinitial temperature is 60 DEG C and increased to 180 DEG C at the rate of 20 DEG C/min, and the temperature is kept for 5 minutes, increased to 200 DEG C at the rate of 20 DEG C/min and kept for 3 minutes. The detection method is simple to operate, strong in specificity, good in peak shape, high in sensitivity, good in accuracy and repeatability, the results are reliable, the trimethylacetic acidcan be rapidly analyzed,