ANTI-PD-L1 AND IL-2 CYTOKINES

The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines comprising an anti-PD-L1 antibody fused to a cytokine, such as IL-2. The present invention also provides methods of treatment, uses and pharmaceutical...

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Main Authors CAMPBELL JAMIE, SANDY NIKOLE, ARKINSTALL STEPHEN JOHN, GERMASCHEWSKI VOLKER, DEANTONIO CECILIA, KIRBY IAN, GALLAGHER THOMAS, VAN KRINKS CASSANDRA, KOSMAC MIHA, GILLIES STEPHEN DOUGLAS
Format Patent
LanguageChinese
English
Published 15.03.2019
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Abstract The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines comprising an anti-PD-L1 antibody fused to a cytokine, such as IL-2. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines. 本发明是关于抗PD-L1抗体、含有对PD-L1具有特异性的个结构域的双特异性抗体，且是关于包含稠合到细胞因子，如IL-2的抗PD-L1抗体的免疫细胞因子。本发明还提供治疗方法、用途和包含所述抗体、双特异性抗体和免疫细胞因子的医药组合物。
AbstractList The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines comprising an anti-PD-L1 antibody fused to a cytokine, such as IL-2. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines. 本发明是关于抗PD-L1抗体、含有对PD-L1具有特异性的个结构域的双特异性抗体，且是关于包含稠合到细胞因子，如IL-2的抗PD-L1抗体的免疫细胞因子。本发明还提供治疗方法、用途和包含所述抗体、双特异性抗体和免疫细胞因子的医药组合物。
Author KOSMAC MIHA
CAMPBELL JAMIE
GERMASCHEWSKI VOLKER
GILLIES STEPHEN DOUGLAS
ARKINSTALL STEPHEN JOHN
KIRBY IAN
DEANTONIO CECILIA
SANDY NIKOLE
GALLAGHER THOMAS
VAN KRINKS CASSANDRA
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– fullname: GALLAGHER THOMAS
– fullname: VAN KRINKS CASSANDRA
– fullname: KOSMAC MIHA
– fullname: GILLIES STEPHEN DOUGLAS
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Snippet The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines...
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title ANTI-PD-L1 AND IL-2 CYTOKINES
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