ANTI-PD-L1 AND IL-2 CYTOKINES

• Main Authors: CAMPBELL JAMIE, SANDY NIKOLE, ARKINSTALL STEPHEN JOHN, GERMASCHEWSKI VOLKER, DEANTONIO CECILIA, KIRBY IAN, GALLAGHER THOMAS, VAN KRINKS CASSANDRA, KOSMAC MIHA, GILLIES STEPHEN DOUGLAS
• Format: Patent
• Language: Chinese; English
• Published: 15.03.2019
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to anti-PD-L1 antibodies, bispecific antibodies containing one domain with specificity to PD-L1, and to immunocytokines comprising an anti-PD-L1 antibody fused to a cytokine, such as IL-2. The present invention also provides methods of treatment, uses and pharmaceutical compositions comprising the antibodies, bispecific antibodies and immunocytokines. 本发明是关于抗PD-L1抗体、含有对PD-L1具有特异性的个结构域的双特异性抗体，且是关于包含稠合到细胞因子，如IL-2的抗PD-L1抗体的免疫细胞因子。本发明还提供治疗方法、用途和包含所述抗体、双特异性抗体和免疫细胞因子的医药组合物。