Method for synthesizing N-acetylquinoxaline-2-acylamide and derivatives thereof

• Main Authors: BAO HANYANG, LIU LIANYAN, LIU YUNKUI
• Format: Patent
• Language: Chinese; English
• Published: 05.03.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a method for synthesizing N-acetylquinoxaline-2-acylamide and derivatives thereof. The method comprises the steps of using a 2-quinoxalinecarbaldehyde compound represented by aformula I or formula III as an initial substance, dissolving the 2-quinoxalinecarbaldehyde compound in a mixed solvent, conducting a reaction at 40 to 80 DEG C for 3 to 12 hours under the action of acopper catalyst and an oxidizing agent, and conducting post-treatment on an obtained reaction liquid to obtain the N-acetylquinoxaline-2-acylamide and derivatives thereof represented by a formula IIor formula IV, wherein the copper catalyst is copper(II) trifluoromethanesulfonate, copper acetate or copper chloride, the oxidizing agent is one or more of ammonium persulfate, potassium persulfate,2,3-dichloro-5,6-dicyano-1,4-benzoquinone or a 70 wt% t-butanol peroxide aqueous solution, the mixed solvent is a mixed solution of acetonitrile and water in a volume ratio of (5-100):1, and the molarratio of the catalyst to the