Immune-enhanced recombinant PRRSV (Porcine Reproductive and Respiratory Syndrome Virus)-like particle subunit vaccine

The invention discloses an immune-enhanced recombinant PRRSV (Porcine Reproductive and Respiratory Syndrome Virus)-like particle subunit vaccine. The immune-enhanced recombinant PRRSV virus-like particle subunit vaccine consists of PRRSV-like particles and a compound immunologic adjuvant. The immune...

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Bibliographic Details
Main Authors DONG JIANHUI, CHEN RUI, DU ENQI
Format Patent
LanguageChinese
English
Published 01.03.2019
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Summary:The invention discloses an immune-enhanced recombinant PRRSV (Porcine Reproductive and Respiratory Syndrome Virus)-like particle subunit vaccine. The immune-enhanced recombinant PRRSV virus-like particle subunit vaccine consists of PRRSV-like particles and a compound immunologic adjuvant. The immune-enhanced recombinant PRRSV-like particle subunit vaccine disclosed by the invention has the beneficial effects that by the means of gene engineering, PRRSV GP5-M gene is modified, and the PRRSV-like particles with high immunogenicity are prepared by constructing rhabdovirus expression vectors. In addition, by improvement on the immunologic adjuvant, the immune-enhanced recombinant PRRSV-like particle subunit vaccine is obtained and the subunit vaccine has a better immune effect. 本发明公开了种免疫增强型重组PRRSV病毒样颗粒亚单位疫苗,由PRRSV病毒样颗粒和复合免疫佐剂组成。本发明通过基因工程的手段,改造了PRRSV GP5-M基因,通过构建杆状病毒表达载体制备得到具有高免疫原性的PRRSV病毒样颗粒。另外,本发明通过免疫佐剂的改进,得到了种免疫增强型重组PRRSV病毒样颗粒亚单位疫苗,该亚单位疫苗具有更好的免疫效果。
Bibliography:Application Number: CN201811321685