Method for detecting isosorbide in isosorbide mononitrate and composition thereof

• Main Authors: DING JINGNAN, TANG JIAOJIAO, SUN HONGZHANG
• Format: Patent
• Language: Chinese; English
• Published: 22.02.2019
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The invention relates to the technical field of chemical analysis and more specifically relates to a method for analyzing isosorbide in isosorbide mononitrate and a composition thereof. The inventionprovides a method for detecting isosorbide in isosorbide mononitrate and a composition thereof. The method comprises the steps: firstly, dissolving isosorbide mononitrate and the composition thereof by using a solvent; then, carrying out separation by using a liquid chromatography; and then, carrying out detection by using a differential refraction detector. The method disclosed by the invention has higher sensitivity than a TLC method and is capable of realizing accurate quantitation. 本发明涉及化学分析技术领域，更具体涉及单硝酸异山梨酯及其组合物中异山梨醇的分析方法。本发明提供了种检测单硝酸异山梨酯及其组合物中异山梨醇的方法，包括：先将单硝酸异山梨酯或组合物在溶剂溶解，然后采用液相色谱法分离，然后采用示差折光检测器检测。本发明的方法比TLC方法灵敏度更高，而且可准确定量。