Hydroxamic acid-containing substituted heterocyclic compound as well as preparation method and application thereof

• Main Authors: YANG KAN, WANG JINXIN, NONG KEYI
• Format: Patent
• Language: Chinese; English
• Published: 22.02.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the field of medicinal chemistry and in particular relates to a hydroxamic acid-containing substituted heterocyclic compound as well as a preparation method and application thereof. The specific structure of the compounds provided by the invention is shown as a formula I, and the compounds have acid sphingomyelinase inhibitory activity. The invention further provides a synthetic method of compounds in the formula I and application of the compounds in atherosclerosis and depression. The compounds can be used for developing related drugs for treating atherosclerosis (AS), diabetes, pulmonary emphysema, pulmonary edema, pulmonary fibrosis, cystic fibrosis, chronic obstructive pulmonary disease, pulmonary arterial hypertension, non-alcoholic fatty liver disease, Alzheimer's disease (AD), multiple sclerosis (MS), cerebral apoplexy and depression. The structural formula is as shown in the specification. 本发明属于药物化学领域，具体涉及种含有异羟肟酸的取代杂环类化合物及其制备方法和用途。本发明提供的该类化合物具体结构为式I所示，具有酸性鞘磷脂酶抑制活性。本发明还提供了式I中化合