Positively charged drug nanocrystal preparation and preparation method thereof

The invention belongs to the field of drug preparations and relates to a positively charged drug nanocrystal preparation capable of being used for mucosal drug delivery and featured with bioadhensionand a preparation method thereof. According to the positively charged drug nanocrystal preparation ca...

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Bibliographic Details
Main Authors HUANG ZHIGANG, WEI GANG, CI LIQIAN, LIU YU, LU WEIYUE
Format Patent
LanguageChinese
English
Published 15.02.2019
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention belongs to the field of drug preparations and relates to a positively charged drug nanocrystal preparation capable of being used for mucosal drug delivery and featured with bioadhensionand a preparation method thereof. According to the positively charged drug nanocrystal preparation capable of being used for mucosal drug delivery and featured with bioadhension, by using a polydopamine coating technique, surface coating and positively charging of drug nanocrystals are realized, so that polydopamine coating layers adhere to the surfaces of the drug nanocrystals and amination modification is carried out on the surfaces of the drug nanocrystals; and therefore, the surfaces of the drug nanocrystals are rich in positive charges, and better adhesion and better stability to biological tissues are given to the drug nanocrystals. The positively charged drug nanocrystal preparation capable of being used for mucosal drug delivery and featured with bioadhension, provided by the invention, has the advantages
Bibliography:Application Number: CN20171644758