OPEN SURFACE GRAPHITIC MATERIALS FOR ADSORPTION OF CYTOKINES FROM BLOOD

• Main Authors: MOCHALIN VADYM, PESCATORE NICHOLAS, GOGOTSI YURY
• Format: Patent
• Language: Chinese; English
• Published: 05.02.2019
• Subjects: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

The present disclosure is directed to methods of removing proteins, including cytokines, from blood and blood products, the methods comprising contacting the blood or blood product with a form of carbon having high graphitic contents and slit-shaped mesopores and macropores, the pore size dimensions chosen to be comparable to the size of the proteins, wherein the contacting results in the removalof high levels of the protein from the blood or blood product in minutes or hours. 本公开涉及种从血液和血液制品中除去蛋白质、包括细胞因子的方法，所述方法包括将所述血液或血液制品与具有高石墨含量和狭缝形中孔和大孔的碳形式接触，所述孔隙尺寸被选择成与所述蛋白质的尺寸相当，其中所述接触导致在数分钟或数小时内从所述血液或血液制品除去高水平的所述蛋白质。