FUSED PENTACYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY

• Main Authors: HEER JAG PAUL, KEYAERTS JEAN
• Format: Patent
• Language: Chinese; English
• Published: 15.01.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A series of fused pentacyclic imidazole derivatives, being potent modulators of f benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders;neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 5,7,8,15-tetrahydro-6H-8,15- methanobenzimidazo[1,2-b][2,5]benzodiazocin-6-one derivatives and analogs thereof. 系列稠合五环咪唑衍生物，为有效的调节剂，因此有益于治疗和/或预防多种人类疾病，包括自身免疫性和炎症性疾病；神经学和神经变性疾病；疼痛和伤害感受性疾病；心血管疾病；代谢疾病；眼疾病；和肿瘤学疾病。特别地，本发明涉及5,7,8,15-四氢-6H-8,15-甲桥苯并咪唑并[1,2-b][2,5]苯并二氮杂环辛四烯-6-酮衍生物及其类似物。