BIOACTIVE BOROPHOSPHATE GLASSES

• Main Authors: FANG YE, FU QIANG, DENG HUAYUN, LI AIZE, MAURO JOHN CHRISTOPHER, MA LINA
• Format: Patent
• Language: Chinese; English
• Published: 11.01.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMICAL COMPOSITION OF GLASSES, GLAZES, OR VITREOUSENAMELS; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; ENZYMOLOGY; GLASS; HUMAN NECESSITIES; HYGIENE; JOINING GLASS TO GLASS OR OTHER MATERIALS; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MINERAL OR SLAG WOOL; MUTATION OR GENETIC ENGINEERING; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS,MINERALS OR SLAGS; SURFACE TREATMENT OF GLASS; VINEGAR; WINE

A borophosphate glass composition including B2O3, P2O5 and CaO, and optionally a source additive selected from: Li2O, Na2O, K2O, A12O3, ZnO, MgO, Fe2O3/FeO, CuO/Cu2O, and mixtures thereof, as definedherein. Also disclosed are bioactive compositions or substrates including the disclosed borophosphate glass composition, and at least one live cell. Also disclosed are methods of inhibiting or increasing the relative amount of species containing boron, phosphorous, or both, being released into an aqueous solution from aborophosphate glass composition defined herein. Also disclosed is a method of proliferating cells on a bioactive substrate as defined herein. Also disclosed are related glass compositions that exclude one of B2O3, P2O5, and CaO. 硼磷酸盐玻璃组合物包含BO、PO、和CaO，任选地包含选自LiO、NaO、KO、AlO、ZnO、MgO、FeO/FeO、CuO/CuO及其混合物的源添加剂，如本文所定义。还揭示了生物活性组合物或基材，其包含所揭示的硼磷酸盐玻璃组合物和至少种活细胞。还揭示了对含硼物质和/或含磷物质从本文所定义的硼磷酸盐玻璃组合物释放到水性溶液中的相对量进行抑制或增加的方法。如本文所定义，还揭示了在生物活性基材上增殖细胞的方法。还揭示了排除了BO、PO、和CaO中的种的相关玻璃组合物。