In-situ reactive oxygen species and myeloperoxidase responsive self-luminous polymer material as well as preparation method and application thereof

• Main Authors: ZHANG DINGLIN, XU XIAOQIU, DOU YIN, AN HUIJIE, ZHANG JIANXIANG
• Format: Patent
• Language: Chinese; English
• Published: 08.01.2019
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; ORGANIC MACROMOLECULAR COMPOUNDS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP

The invention discloses an in-situ reactive oxygen species and myeloperoxidase responsive self-luminous polymer material as well as a preparation method and application thereof and belongs to the field of biomedicines. The in-situ reactive oxygen species and myeloperoxidase responsive self-luminous polymer material has a chemical structure shown as follows. The in-situ reactive oxygen species andmyeloperoxidase responsive self-luminous polymer material takes photo-sensitizer porphyrin e6 as a basic skeleton and is chemically bonded with chemiluminescent small molecule luminol or a derivativethereof and polyethylene glycol. Nano-particles are formed by self-assembly in an aqueous solution, the specificity responds to a highly-reactive oxygen species and myeloperoxidase horizontal micro-environment, and based on a chemiluminescence resonance energy transfer effect, near-infrared light is emitted for self-luminous imaging; an in-situ photodynamic therapy function is played along with the generation of singlet ox