BIODEGRADABLE SOFT TISSUE FILLER

• Main Authors: LEONG LIANG WEY, SANTERRE PAUL, SHARIFPOOR SOROR
• Format: Patent
• Language: Chinese; English
• Published: 04.01.2019
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A soft tissue filler comprising a biodegradable amino-acid derived polycarbonate-urethanes and methods of repairing soft tissue defects are provided. The biodegradable soft tissue filler comprises a porous scaffold that is the reaction product of: a) a divinyl oligomer component that comprises a carbonate-derived divinyl oligomer that is the reaction product of a lysine-derived diisocyanate, a vinyl coupling agent, and a polycarbonate and, optionally, an ether-derived divinyl oligomer, wherein the ether-derived divinyl oligomer is the reaction product of a lysine-derived diisocyanate, a vinylcoupling agent, and an ether; b) at least one anionic monomer; and c) at least one hydrophobic monomer. The molar ratio of (a) : (b+c) is between about 1>=21 and about 1:30, the soft tissue filler hasa porosity of > 75 %; and a compressive moduli of between about 1 kPa and about 50 kPa. 提供了软组织填充物和修复软组织缺损的方法，所述软组织填充物包含氨基酸衍生的可生物降解型聚碳酸酯-尿烷。所述可生物降解型软组织填充物包括多孔支架，所述多孔支架是以下项的反应产物：a)二乙烯基寡聚物组分，其包含碳酸酯衍生的二乙烯基寡聚物以及任选地醚衍生的二乙烯基寡聚物，所述碳酸