DIPEPTIDYL PEPTIDASE-4 INHIBITORS FOR TOPICAL EYE TREATMENT OF RETINAL NEURODEGENERATIVE DISEASES

• Main Authors: HERNANDEZ PASCUAL CRISTINA, SIMO CANONGE RAFAEL
• Format: Patent
• Language: Chinese; English
• Published: 04.01.2019
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to dipeptidyl peptidase-4 inhibitors, including saxagliptin and sitagliptin, for use in the topical eye treatment and/or prevention of retinal neurodegenerative diseases, in particulardiabetic retinopathyand its associated microvascular impairment. The invention also encompasses pharmaceutical topicaleyecompositions for use in the topicaltreatment and/or prevention of these diseases. 本发明涉及用于局部眼部治疗和/或预防视网膜神经退行性疾病、特别是糖尿病视网膜病变及其相关的微血管损伤的二肽基肽酶-4抑制剂，包括沙格列汀和西格列汀。本发明还包括用于局部治疗和/或预防这些疾病的药物局部眼用组合物。