Ertapenem disodium medicine composition and preparation method thereof

The invention relates to an ertapenem disodium medicine composition and a preparation method thereof. The medicine composition contains ertapenem disodium shown in the formula 1, and a compound shownin the formula 2 or sodium salts or hydrates or solvent products and pharmaceutically-acceptable auxi...

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Bibliographic Details
Main Authors CHEN YAPING, SHI YING, HAO WEIHUA, BAI MIN, KANG HONGYAN, GONG DENGHUANG, ZHANG YARAN
Format Patent
LanguageChinese
English
Published 04.01.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to an ertapenem disodium medicine composition and a preparation method thereof. The medicine composition contains ertapenem disodium shown in the formula 1, and a compound shownin the formula 2 or sodium salts or hydrates or solvent products and pharmaceutically-acceptable auxiliary materials. The compound shown in the formula 2 or pharmaceutical salts or hydrates or solventproducts in the Ertapenem disodium solid medicine composition reaches up to 80% or more, and the stability of the final Ertapenem disodium preparation is greatly improved. 本发明涉及种厄他培南钠固态药物组合物及其制备方法，所述药物组合物含有式1所示的厄他培南钠，和式2所示的化合物或其钠盐、水合物或溶剂化物，以及药学上可接受的辅料。本发明提供的厄他培南钠固态药物组合物中式2化合物或其可药用的盐、水合物或溶剂化物所占比例高达80％以上，大大提高了厄他培南钠最终制剂的稳定性。
Bibliography:Application Number: CN20181683783