Asymmetric synthesis method for crinum asiaticum alkaloid

• Main Authors: XIE JIANHUA, ZHOU QILIN, ZUO XIAODONG, WANG LIXIN
• Format: Patent
• Language: Chinese; English
• Published: 04.01.2019
• Subjects: APPARATUS THEREFOR; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

The invention relates to an asymmetric synthesis method for crinum asiaticum alkaloid taking the asymmetric catalytic hydrogenation reaction as the key step. According to the method, through racemic asymmetric catalytic hydrogenation kinetic resolution for replacing cyclohexanone, quick asymmetric synthesis for 22 kinds of crinum asiaticum alkaloid comprising (-)-crinine, (+)-epivittatine, (+)-vittatine, (-)-epicrinine and the like and eight analogues is achieved concisely and efficiently. 本发明涉及种以不对称催化氢化反应为关键步骤的不对称合成文殊兰类生物碱的方法，该方法通过消旋的取代环己烯酮的不对称催化氢化动力学拆分，简洁、高效地实现了包括(-)-crinine，(+)-epivittatine，(+)-vittatine，(-)-epicrinine等22个文殊兰类生物碱及8个类似物的快速不对称合成。