Devices and methods for selecting apoptosis-signaling resistant cells, and uses thereof

• Main Authors: YARKONI SHAI, ASHKENAZI NADIR
• Format: Patent
• Language: Chinese; English
• Published: 01.01.2019
• Subjects: HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; TESTING

The present invention discloses a device and a kit adapted for selection of cells that are resistant to receptor-mediated apoptosis and a method for using the device and kit. The device enables negative selection of mature immune cells which induce graft versus host disease (GvHD) out of a heterogeneous cell population which is introduced into the device. The device enables an efficient cell selection in simplified and cheaper setting by an off the shelf product - a solution that currently do not exist. The present invention further discloses uses for the device. 本发明公开了适于选择对受体介导的细胞凋亡具有抗性的细胞的种装置和种试剂盒以及种使用所述装置和试剂盒的方法。所述装置能够对从引入所述装置中的异源细胞群体中诱导移植物抗宿主疾病(GvHD)的成熟免疫细胞进行阴性选择。所述装置通过现货供应产品-当前并不存在的方案来以简化和更廉价的设置实现有效的细胞选择。本发明进步公开所述装置的用途。