Dibenzyl dimer compound and method and application for extracting and separating compound from dendrobium stems

• Main Authors: HE YUQI, ZHANG MAOSHENG, CHEN YONGZHENG, XIAO SHIJI, NIE XUQIANG, ZHANG JIANYONG, SHANG ZHIMEI, LI XIAOFEI
• Format: Patent
• Language: Chinese; English
• Published: 28.12.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a dibenzyl dimer compound and method and application for extracting and separating the compound from dendrobium stems in the technical field of plant effective ingredient extraction. The method is characterized in that an extraction method and a column chromatography are adopted to enrich ingredients, a method for refining with a modern chromatography separating method is adopted to separate and purify the complicated ingredients from the dendrobium stems. By adopting the provided preparation method, a dibenzyl dimer is successively extracted and separated from the dendrobium stems, and the dibenzyl dimer has very good antitumor in-vitro cellular activity and can be used for preparing antitumor drugs. 本方案公开了植物有效成分提取技术领域的种联苄基二聚体类化合物及其从金钗石斛中提取分离的方法与应用。本发明的特点是采用萃取法和柱色谱法富集成分，现代色谱分离法精制的方法从金钗石斛中分离纯化此类较为复杂的成分。本发明提供的制备方法成功从金钗石斛中提取分离得到种联苄基二聚体成分，这种成分具有很好的体外抗肿瘤细胞活性，可用于制备抗肿瘤药物。