BENZIMIDAZOLE DERIVATIVES AS MODULATORS OF ROR-GAMMA

• Main Authors: LOTESTA STEPHEN D, SINGH SURESH B, DILLARD LAWRENCE WAYNE, ZHAO WEI, ZHUANG LINGHANG, TICE COLIN M, CLAREMON DAVID A, FAN YI
• Format: Patent
• Language: Chinese; English
• Published: 21.12.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided are novel compounds of Formula I, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by RORy. Also provided are pharmaceutical compositions comprising the novel compounds of Formula I and methods for their use in treating one or more inflammatory, metabolic, autoimmune and other diseasesor disorders. 本发明提供了式I的新型化合物，其可药用盐及其药物组合物，所述化合物可用于治疗由RORy介导的疾病和障碍。还提供了包含式I的新型化合物的药物组合物，以及将其用于治疗种或多种炎性、代谢、自身免疫和其他疾病或障碍的方法。