Preparation method of 5-aminomethyl-piperidin-2-one

• Main Authors: BAI FENG, JIANG DEHONG, HU QUANFANG
• Format: Patent
• Language: Chinese; English
• Published: 14.12.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a preparation method of 5-aminomethyl-piperidin-2-one. The preparation method comprises the following step: with 5-aminomethyl-pyridin-2-ol as a raw material, in the presence of an acidic reagent, preparing a 5-aminomethyl-piperidin-2-one product by using platinum dioxide as a catalyst. By the preparation method of the 5-aminomethyl-piperidin-2-one, operating steps are simplified, and the preparation cost is reduced; the using amounts of PtO2 and the reagent are optimized, and the conversion rate and the yield of a target product are increased; use of an irritating, toxic and flammable hazardous chemical reagent is avoided, a reaction condition is mild, the safety is high, and safety hazards to operators are reduced, the operational safety level for production is reduced, and environment friendliness is achieved; the obtained 5-aminomethyl-piperidin-2-one product is high in purity and good in quality, is beneficial to the safety of a medicine synthesized therefrom as an intermediate, a