Solid transdermal therapeutic system comprising UV absorber

• Main Authors: LANGGUTH THOMAS, BRACHT STEFAN
• Format: Patent
• Language: Chinese; English
• Published: 11.12.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a novel solid transdermal therapeutic system which comprises UV absorber and is designed particularly for photosensitive active pharmaceutical substances. Said UV-stable transdermal therapeutic system (TTS) is composed of a rear layer (1), at least one active substance-containing matrix (2), and a peelable protective film (3). An adhesive layer (4) and a separating layer (5) are selectively inserted between the rear layer (1) and the active substance-containing matrix (2). UV absorbers from the group of hydroxyphenyltriazines can be embedded in the rear layer (1), theactive substance-containing matrix (2), or the adhesive layer (4). The inventive TTS is provided with great stability while having a low UV absorber concentration, thus preventing or reducing especially the risk of a potential skin irritation. 本发明涉及具有UV吸收剂的新型固态透皮治疗系统，其特别设计用于光敏活性药物成分。所述UV-稳定透皮治疗系统(TTS)由背衬层1、至少个含活性成分的基质层2、及可分离的保护膜3组成，任选地在背衬层1和含活性成分的基质层2之间引入粘合层4和隔离层5。选自羟苯基三嗪类的UV吸收剂可以包埋在背衬层1或含活性成分的基质层2或粘合层4中。根据本发明的TTS以低的UV吸收剂