Formulations containing amorphous dapagliflozin

• Main Authors: GRMAS JERNEJ, STARIC ROK, GRAHEK ROK, STANIC LJUBIN TIJANA, BERGLEZ SANDRA, PETERNEL LUKA
• Format: Patent
• Language: Chinese; English
• Published: 07.12.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Formulations containing amorphous dapagliflozin. The present invention belongs to the field of pharmaceutical industry and relates to an amorphous solid dispersion comprising at least one polymer anddapagliflozin, to a pharmaceutical composition comprising said solid dispersion, to a process for the preparation thereof, and to the solid dispersion and pharmaceutical composition respectively obtainable by said process. Further, the present invention refers to an adsorbate comprising dapagliflozin and to a pharmaceutical composition comprising said adsorbate, as well as to a process for the preparation thereof. Finally, the present invention relates to the solid dispersion, the adsorbate or the pharmaceutical composition for use in the treatment of diseases related to hypoglycemia. 本发明涉及包含无定形达格列净的制剂。本发明属于制药工业领域，并且涉及包含至少种聚合物和达格列净的无定形固体分散体，包含所述的固体分散体的药物组合物，其制备方法以及通过所述的方法分别可获得的固体分散体和药物组合物。此外，本发明涉及包含达格列净的吸附物和包含所述的吸附物的药物组合物，以及其制备方法。最后，本发明涉及固体分散体、吸附物或药物组合物，其用于治疗与降血糖相关的疾病。