2-methylene type substituted secolignan derivative and pharmaceutical use thereof

• Main Authors: ZHAO YIMIN, YANG YU, XU RUI, SUN RUOFENG, YU NENGJIANG
• Format: Patent
• Language: Chinese; English
• Published: 04.12.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a 2-methenene type substituted secolignan derivative and pharmaceutical use thereof, and in particular relates to a compound having a structure of a formula I or pharmaceutically acceptable salts thereof, a pharmaceutical composition containing the compound or pharmaceutically acceptable salts of the compound, use of the compound or pharmaceutically acceptable salts of the compound for preparation of a medicament taking a JAK-STAT signal pathway as a target site, and use of the compound or pharmaceutically acceptable salts of the compound for preventing and/ortreating a JAK-STAT signal pathway-related disease of a subject. 本发明涉及2-甲烯基型取代型裂木脂素类衍生物及其医药用途，具体涉及具有式I所示结构的化合物或其药学上可接受的盐，含有所述化合物或其药学上可接受的盐的药物组合物，所述化合物或其药学上可接受的盐在制备以JAK-STAT信号通路为靶点的药物中的用途，以及所述化合物或其药学上可接受的盐用于预防和/或治疗受试者的JAK-STAT信号通路相关疾病的用途。