External-used drug using high skin permeability of carbomer synergistic transdermal agent for prevention and treatment of periarthritis of shoulders

• Main Authors: TAN ZHENGHUAI, LIU HONG, QIU JIANPING, CHEN HUIXU, ZENG MINGHUI, XIONG JINGYUE
• Format: Patent
• Language: Chinese; English
• Published: 30.11.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses an external-used drug using high skin permeability of a carbomer synergistic transdermal agent for prevention and treatment of periarthritis of shoulders, and by mixed combination of carbomer, azone, Chuanxiong rhizome oil and a transdermal agent, the skin permeability of effective pharmaceutical ingredient NAB can be promoted, the mass content of a matrix is 0.5% to 1.2%,the mass content of the transdermal agent is 0.5% to 10%, and the mass ratio of the azone to the Chuanxiong rhizome oil is 2:3. The mass content of ligustilide in the Chuanxiong rhizome oil is greaterthan or equal to 30%, and the mass content of the NAB is 0.5% to 2.0%. The carbomer as the matrix can promote the more significant synergistic effect of the azone and the Chuanxiong rhizome oil, so that the external-used drug with the NAB as the effective pharmaceutical ingredient for preventing and treating the periarthritis of the shoulders has high skin permeability, and the therapeutic effectis remarkably improved. 本发