Application of 6-chloro-5-nitro-2,4-diaminopyrimidine in drug for treating chronic granulocytic leukemia

• Main Authors: SHI KAIQI, TANG YONGHONG, LIANG CHENGYUAN, TIAN DANNI, XIA JUAN, CHANG MINGHUI, WANG XUECHUAN, LI HAN
• Format: Patent
• Language: Chinese; English
• Published: 30.11.2018
• Subjects: APPARATUS THEREFOR; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses application of 6-chloro-5-nitro-2,4-diaminopyrimidine in a drug for treating chronic granulocytic leukemia. A synthesis method for the 6-chloro-5-nitro-2,4-diaminopyrimidine ischaracterized in that a target compound is prepared by reacting guanidine hydrochloride, amino formyl ethyl acetate and NaClO in an organic solvent under an acidic condition. According to the experimental research, the 6-chloro-5-nitro-2,4-diaminopyrimidine is firstly found to have excellent CML resistance, and can be used for preparing the drug for treating CML. 本发明公开了6-氯-5-硝基-2,4-二氨基嘧啶在治疗慢性粒细胞白血病药物中的应用，所述6-氯-5-硝基-2,4-二氨基嘧啶的合成方法是以盐酸胍、氨基甲酰乙酸乙酯和NaClO在酸性条件下于有机溶剂中反应制得目标化合物。本发明通过实验研究首次发现6-氯-5-硝基-2,4-二氨基嘧啶具有优良的抗CML药效，可以用于制备治疗CML的药物。