Solid dispersions comprising sGC stimulator

The present invention relates to solid dispersions of amorphous 1,1,1,3,3,3-hexafluoro-2-(((5-fluoro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidin-4-yl)amino)methyl)propan-2-ol (Compound I) or a pharmaceutically acceptable salt thereof. It also relates to pharmaceutical compositi...

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Bibliographic Details
Main Authors SETHURAMAN VASU, HASHASH AHMAD, DUNBAR CRAIG ANTHONY
Format Patent
LanguageChinese
English
Published 23.11.2018
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to solid dispersions of amorphous 1,1,1,3,3,3-hexafluoro-2-(((5-fluoro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidin-4-yl)amino)methyl)propan-2-ol (Compound I) or a pharmaceutically acceptable salt thereof. It also relates to pharmaceutical compositions and pharmaceutical oral dosage unit forms comprising them, and their uses thereof. 本发明涉及无定形1,1,1,3,3,3-六氟-2-(((5-氟-2-(1-(2-氟苄基)-5-(异噁唑-3-基)-1H-吡唑-3-基)嘧啶-4-基)氨基)甲基)丙-2-醇(化合物I)的固体分散体或其药学上可接受的盐。它还涉及包含它们的药物组合物和药物口服剂量单位形式及其用途。
Bibliography:Application Number: CN201680077389