Porcine albumin-interferon alpha-interleukin 2 fusion protein, preparation method as well as coding gene thereof, and porcine pegylated interferon
The invention discloses a porcine albumin-interferon alpha-interleukin 2 fusion protein, a preparation method as well as a coding gene thereof, and porcine pegylated interferon. Porcine albumin, porcine interferon alpha and porcine interleukin 2 are connected through a flexible linker to obtain the...
Saved in:
Main Authors | , , , , , , , |
---|---|
Format | Patent |
Language | Chinese English |
Published |
20.11.2018
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The invention discloses a porcine albumin-interferon alpha-interleukin 2 fusion protein, a preparation method as well as a coding gene thereof, and porcine pegylated interferon. Porcine albumin, porcine interferon alpha and porcine interleukin 2 are connected through a flexible linker to obtain the porcine albumin-interferon alpha-interleukin 2 fusion protein, the coding gene of the fusion proteinis designed to be optimized, and the recombinant porcine pegylated interferon is prepared finally; the porcine pegylated interferon can significantly improve a half-life period of porcine interferon,which is 27 times or more than 27 times of the half-life period of ordinary porcine interferon, has a broad-spectrum antiviral effect, and can improve the immune response of pigs themselves.
本发明公开了猪白蛋白-干扰素α-白介素2融合蛋白、制备方法及其编码基因、种猪长效干扰素,将猪白蛋白、猪干扰素α和猪白介素2通过柔性linker连接,得到猪白蛋白-干扰素α-白介素2融合蛋白,设计优化其编码基因,最终制备得到重组猪长效干扰素,可显著提高猪干扰素的半衰期,较普通猪干扰素的半衰期提高27倍以上,并具有广谱抗病毒作用并能提高猪自身的免疫应答。 |
---|---|
Bibliography: | Application Number: CN201810751030 |