Pyrimidines compounds

A pyrimidine derivative represented by general formula (II) or (III) and a salt thereof, both having selective acetylcholine esterase inhibitor and type A monoamine oxidase inhibitor effects, thus being useful as antidepressant and senile dementia remedy. In said formulae, R and R represent each H,...

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Bibliographic Details
Main Authors YOSHIAKI KUROKI, HIROSHI FUJIWARA, TOMIO KIMURA
Format Patent
LanguageEnglish
Published 22.06.1994
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A pyrimidine derivative represented by general formula (II) or (III) and a salt thereof, both having selective acetylcholine esterase inhibitor and type A monoamine oxidase inhibitor effects, thus being useful as antidepressant and senile dementia remedy. In said formulae, R and R represent each H, halogen, amino, nitro, (un)substituted alkyl, alkoxy or alkoxycarbonyl, provided that R and R may be combined together to represent (un)substituted alkylene; R represents aralkyl or heteroaryl-alkyl; R represents H or acyl; R represents H, OH or alkoxy; R represents H, halogen, alkyl or alkoxy; X represents -CH=, -CH=CH-(CH2)p-, -CH2- or -CH2CH2-(CH2)p-; Y represents =CH-(CH2)p-, -CH2-(CH2)p-, single bond or double bond; p represents 0 or 1; and symbol @ represents either single or double bond.
Bibliography:Application Number: CN19931018642