Method for analysis of fluoromethyl-1,1,1,3,3,3-hexafluoroisopropylether

• Main Authors: TOSHIKAZU KAWAI, MINEO WATANABE, TAKAAKI YOSHIMURA
• Format: Patent
• Language: English
• Published: 24.07.2002
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; METALLURGY; ORGANIC CHEMISTRY; PHYSICS; TESTING

The present invention provides a method in which organic matter in the product accompanied with a non-reacted hydrogen fluoride can be handled without damaging the apparatus, using a cross-linked cyanopropylmethylphenylsilicone capillary column with which impurities of very small amounts can be separated, and with which non-reacted raw materials and by-products, which have a wide range of boiling points can be quantitated. The present invention further provides a process control method of a production method of SEVOFLURANE, which is characterized in that the content of a particular component in one of the following steps is determined and in that, assuming this as a variable, the treatment condition of the step is adjusted: 1) a step of reacting together 1,1,1,3,3,3-hexafluoroisopropyl alcohol, (para) formaldehyde, and hydrogen fluoride in the presence of sulfuric acid; 2) a step of contacting a crude fluoromethyl-1,1,1,3,3,3-hexafluoroisopropyl ether with an alkali aqueous solution and/or water; and 3) a step of distilling crude SEVOFLURANE.