Rapamycin slow-release dosage form as well as preparation method, rapamycin slow-release injection and application

• Main Authors: BAI XIAOCHUN, YANG XIAO, CUI ZHONGKAI, ZHANG HAIYAN, LI KAI
• Format: Patent
• Language: Chinese; English
• Published: 09.11.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides a rapamycin slow-release dosage form as well as a preparation method, a rapamycin slow-release injection and application, which relate to the technical field of medicines. The rapamycin slow-release dosage form comprises rapamycin and a slow-release material in a mass ratio of 1: (10 to 50). The rapamycin slow-release dosage form is high in drug content, capable of realizinga slow-release and controlled-release effect of a drug, and capable of effectively alleviating and treating osteoarthritis. The preparation method of the rapamycin slow-release dosage form provided by the invention is simple to operate, and the prepared rapamycin slow-release dosage form is good in stability, long in retention time in a human body, high in bioavailability, and favorable for the popularization and application of industrialized production. The rapamycin slow-release injection can be directly injected without using an organic solvent, can reduce the adverse reaction and safety accidents caused by the or