EPITHELIAL CANCER EVALUATION USING BETA DEFENSIN

• Main Authors: WEINBERG AARON, GURKAN UMUT A, GHOSH SANTOSH
• Format: Patent
• Language: Chinese; English
• Published: 06.11.2018
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; TESTING; VINEGAR; WINE

A method of detecting epithelial cancer is described that includes the steps of: (a) determining the level of beta defensin 3 (BD-3) and beta defensin 2 (BD-2) in a suspect sample obtained from a subject; (b) comparing the level of BD-3 to BD-2 determined in the suspect sample to obtain a suspect BD-3/BD-2 ratio, (c) comparing the suspect BD-3/BD-2 ratio to a healthy BD-3/BD-2 ratio to obtain a diagnostic BD-3/BD-2 ratio; and (d) characterizing the subject as having epithelial cancer if the diagnostic BD-3/BD-2 ratio is greater than 1. A microfluidic device for detecting epithelial cancer using the diagnostic BD-3/BD-2 ratio is also described. 描述了种检测上皮癌的方法，该方法包括步骤：(a)在受试者的可疑样本中测定β防御素3(BD-3)和β防御素2(BD-2)的水平；(b)比较可疑样本中确定的BD-3和BD-2的水平，以获得可疑B。D-3/BD-2比值，(c)将可疑BD-3/BD-2比值与健康的BD-3/BD-2比值进行比较，以获得诊断BD 3/BD-2比值；和(D)如果诊断BD 3/BD-2比值大于1，则将受试者定性为上皮癌。还描述了使用诊断BD 3/BD-2比值检测上皮癌的微流控装置。