AMPD1 as novel diagnostic marker

• Main Authors: XIANG CHANGJUAN, JIA HONGYI
• Format: Patent
• Language: Chinese; English
• Published: 19.10.2018
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

The invention discloses an AMPD1 gene capable of being used as a diagnostic tool for dengue fever and dengue hemorrhagic fever. The high-throughput sequencing and reverse transcription PCR research finds that the content of the AMPD1 gene in blood of patients suffering from the dengue fever and dengue hemorrhagic fever is remarkably higher than that of a normal person. Therefore, the AMPD1 gene can be used as a molecular marker for diagnosing the dengue fever and dengue hemorrhagic fever. The content of the gene expression product in blood represents the dengue fever and dengue hemorrhagic fever, so that the AMPD1 gene has the advantages as follows: the tissue sampling test is avoided, the pain of a subject is relieved, and meanwhile the representation method can be used for screening healthy persons, so that occurrence of the dengue fever and dengue hemorrhagic fever is effectively prevented. 本发明公开了AMPD1基因可作为登革热和登革出血热的诊断工具。本发明通过高通量测序和反转录PCR研究获知，AMPD1基因在登革热和登革出血热患者的血液中含量比正常人显著升高。因此AMPD1基因可以作为诊断登革热和登革出血热的分子标志物