Kit for diagnosing human enterovirus type 71 infection

• Main Authors: HU YUNWEN, YUAN ZHENGHONG, ZHANG HUIYING, ZHANG XIAOLING, SONG ZHIGANG
• Format: Patent
• Language: Chinese; English
• Published: 16.10.2018
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

The invention provides a kit for diagnosing human enterovirus type 71 infection. The test kit comprises one or more solid carriers, and polypeptides, represented by SEQ ID NO: 1 to 6, independently connected to the solid carrier(s). When the response or not of all of the polypeptides represented by SEQ ID NO:1 to 6 are responsive to IgM in a blood sample derived from a subject is used as an indicator for determining whether the subject is infected with human enterovirus type 71 or not, the human enterovirus 71 infection can be diagnosed at a sensitivity of 92% or more and a false positive rateof 5% or less. 本发明提供可用于诊断人肠道病毒71型感染的试剂盒。本发明的检测试剂盒包括个或多个固体载体、以及独立地连接于所述固体载体上的SEQ ID NO：1~6所示的多肽。当以是否SEQ ID NO：1~6所示的多肽全部对受试者来源的血液样本中的IgM有响应作为判定受试者是否已被人肠道病毒71型感染的指标的情况下，可以以92%以上的灵敏度和5%以下的假阳性率诊断人肠道病毒71型感染。