Separating and purifying method of 4-(hydroxymethylphosphinyl)-2-oxobutyrate mother liquor

• Main Authors: ZENG HUI, ZHOU LINJUN, CHEN HUAPING, ZHAO GUANGFU, WANG JIAO
• Format: Patent
• Language: Chinese; English
• Published: 25.09.2018
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention provides a separating and purifying method of a 4-(hydroxymethylphosphinyl)-2-oxobutyrate mother liquor, and relates to the technical field of compound purification. The separating and purifying method comprises the following steps: salifying: performing spin-drying on the 4-(hydroxymethylphosphinyl)-2-oxobutyrate mother liquor and then dissolving in a proper amount of water, regulating the pH value to 4-5 with an aqueous alkali solution with appropriate concentration, separating out salt, and filtering to obtain a mixed solution; flushing and separating out: adding an anti-solvent in the mixed solution, performing agitation crystallization, and filtering to obtain a clear solution; and ion exchange: loading ion exchange resin in an ion exchange column, enabling the obtainedclear solution to pass through the ion exchange column with certain volume at a certain flow rate, eluting with an eluent to obtain colourless liquid, and performing spin-drying to obtain 4-(hydroxymethylphosphinyl)-2-oxobuty