Use of lactobacillus paracasei strain GMNL-653 to prepare composition for resisting bone loss

• Main Authors: CHEN YI HSING, CHOU CHIA HSUAN, TSAI WAN HUA, TSAI PEI JANE, HUANG TSUEI YIN
• Format: Patent
• Language: Chinese; English
• Published: 25.09.2018
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

A use of a Lactobacillus paracasei strain to prepare a composition for resisting bone loss is provided. The Lactobacillus paracasei strain GMNL-653 is capable of promoting the expression of TGF-beta and IL-10, while inhibiting the expression of osteoclast related genes and reducing the content of IL-17A in serum, so that the bone loss is slowed down. 本发明公开种副干酪乳杆菌菌株GMNL-653用于制备抗骨质流失的组合物的用途。所述副干酪乳杆菌菌株GMNL-653具有提高细胞激素TGF-β及IL-10表达，同时抑制蚀骨相关基因及降低细胞激素IL-17A在血清中含量的能力，从而改善骨质流失。