Flavonoid glycoside compound as well as preparation method and application thereof

• Main Authors: ZHAO YIWU, SONG YALING, XIAO WEI, LUO XIN, XIE XUE, WANG XUEJING, WANG ZHENZHONG, LIU LINA
• Format: Patent
• Language: Chinese; English
• Published: 14.09.2018
• Subjects: CHEMISTRY; DERIVATIVES THEREOF; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SUGARS

The invention provides a flavonoid glycoside compound as well as a preparation method and application thereof. The flavonoid glycoside compound has a structure shown in formula I, can obviously reducethe content of LDH and MDA in brain tissues and improve the content of SOD, and has a good protective effect on cerebral ischemia reperfusion injuries of rats. At the same time, the compound can inhibit the growth of tumor cells and has certain anti-tumor activity. 本发明提供了种黄酮苷类化合物及其制备方法和应用，所述黄酮苷类化合物具有式Ⅰ所示结构，该化合物能显著降低脑组织内LDH和MDA含量，并提高SOD含量，对大鼠脑缺血再灌注损伤具有较好的保护作用。同时该化合物能抑制肿瘤细胞生长，具有定的抗肿瘤活性。