Spiro compound used for treating cerebral apoplexy

• Main Authors: ZHOU HAICHUN, WANG YANLI, GUO RUIZHU, HAN DONGWEI, DING YING, MA YUXUAN, ZHANG XIAOJUAN, SUI SIYI
• Format: Patent
• Language: Chinese; English
• Published: 07.09.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a spiro compound used for treating cerebral apoplexy. Shown by a test result, the compound can remarkably improve nerve injury caused by ischemia reperfusion of rice undergoing ischemia reperfusion, can remarkably reduce the cerebral infarction percentage and relieve the edema degree of brain tissue of the rice and can lower the water content. Therefore, the compound has an excellent treatment effect for cerebral apoplexy, especially cerebral arterial thrombosis. 本发明涉及种用于治疗脑卒中的螺环化合物。试验结果表明，本发明化合物可以显著改善脑缺血再灌注小鼠因缺血再灌注引起的神经损伤，能够明显降低其脑梗塞百分比和减轻其脑组织的水肿程度，降低其含水量。因此，本发明化合物对于脑卒中特别是缺血性脑卒中具有优异的治疗作用。