Pharmaceutical compositions comprising phenylaminopyrimidine derivative

• Main Authors: APPADWEDULA VENKATA SATYANARAYANA, ADIBHATLA KALI SATYA BHUJANGA RAO, MOHANTY MITRABHANU, PARVATANENI DURGA MAHESWARI, NANNAPANENI VENKAIAH CHOWDARY
• Format: Patent
• Language: Chinese; English
• Published: 04.09.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

An oral pharmaceutical formulation containing an effective amount of NRC-AN-019 including its pharmaceutically acceptable salts and polymorphs thereof, by dispersing in a polymer system in a final state of subdivision to enhance oral bioavailability. It also relates to processes for the preparation of such compositions and using those compositions for the treatment of Chronic Myeloid Leukemia andother tumors such as head and neck cancer, prostate cancer and the like. 种口服药物制剂，含有有效量的NRC-AN-019，包括其可药用盐及其多晶型物，通过以再分的最终状态分散在聚合物体系中以增强口服生物利用度。其还涉及用于制备这样的组合物的方法和使用那些组合物治疗慢性髓细胞样白血病及其它肿瘤比如头颈癌、前列腺癌等。