MODULATING PERMEABILITY OF THE BLOOD CEREBROSPINAL FLUID BARRIER

• Main Authors: BOIRE ADRIENNE, MASSAGUE JOAN
• Format: Patent
• Language: Chinese; English
• Published: 31.08.2018
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present invention relates to methods and compositions for modulating the blood CSF barrier and for diagnosing, preventing and/or treating leptomeningeal metastasis. In particular embodiments of the invention, the permeability of the blood CSF barrier is modulated by agonists or antagonists of Complement Component 3 (C3) or its receptor. 本发明涉及用于调节血液CSF屏障和用于诊断、预防和/或治疗软脑膜转移的方法和组合物。在本发明的具体实施方式中，血液CSF屏障的通透性由补体成分3(C3)或其受体的激动剂或拮抗剂调节。