METHODS, SYSTEMS, AND APPARATUSES FOR TISSUE ABLATION USING PULSE SHAPE DESIGNS

• Main Authors: RUBINSKY LIEL, GUNTHER ENRIC, RUBINSKY BORIS, MIKUS PAUL, STEHLING MICHAEL KLAUS
• Format: Patent
• Language: Chinese; English
• Published: 31.08.2018
• Subjects: DIAGNOSIS; ELECTROTHERAPY; HUMAN NECESSITIES; HYGIENE; IDENTIFICATION; MAGNETOTHERAPY; MEDICAL OR VETERINARY SCIENCE; RADIATION THERAPY; SURGERY; ULTRASOUND THERAPY

Example methods and apparatuses are disclosed for providing tissue ablation through electrolysis, electroporation, or a combination thereof. A way to deliver the combination through a pulse that has an element of gradual decay and can thereby reduce both muscle contraction and electric breakdown discharge at the electrodes is disclosed. The apparatus disclosed may include an electrode, a power supply, and a controller. The controller may control a charge applied to the electrode to induce a direct current through a treatment site to produce electrolysis products and a voltage to produce electroporation. The duration and magnitude of the charge applied may determine the dose of the products and the degree of the permeabilization of cells in the treatment site. 本发明揭示了用于通过电解、电穿孔或其组合提供组织消融的实例方法及设备。本发明揭示了种用于通过脉冲传递所述组合的方式，所述脉冲具有逐渐衰减元素且可由此减少肌肉收缩及电极处的电击穿放电两者。所揭示的所述设备可包含电极、电源及控制器。所述控制器可控制被施加到所述电极的电荷以引发直流电流通过治疗部位以产生电解产物且引发电压以产生电穿孔。所施加的所述电荷的持续时间及量值可确定所述产物的剂量及所述治疗部位中细胞的透化程度。