Method for preparing N,N-dimethyl-(R)-1-[(S)-2-(diphenylphosphine)ferrocenyl]ethylamine by microreactor

• Main Authors: YANG CUIFENG, XU ZEGANG, LI BINGBO, CHEN TAO, MAO MINGZHEN, WANG YUEMEI, WEI TIANQI, NING BINKE, ZHANG YUANYUAN, SU TIANDUO, ZHANG XIAOGUANG
• Format: Patent
• Language: Chinese; English
• Published: 28.08.2018
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention discloses a method for preparing N,N-dimethyl-(R)-1-[(S)-2-(diphenylphosphine)ferrocenyl]ethylamine by a continuous flow microchannel reactor. The method comprises the following steps that an organic solvent solution of N,N-dimethyl-(R)-1-[(S)-2-ferrocenyl]ethylamine and an n-hexane solution of n-butyllithium are respectively introduced into a microchannel reactor constant temperature module by a metering pump for constant temperature treatment; then, the solutions enter a first mixing module for reaction; after the reaction is completed, the mixed solution enters a second mixingmodule to react with chlorodiphenylphosphine; acidification, extraction, drying and distillation are performed to obtain a crude product of the product of N,N-dimethyl-(R)-1-[(S)-2-(diphenylphosphine)ferrocenyl]ethylamine; the crude product is subjected to alcohol recrystallization to obtain the product of N,N-dimethyl-(R)-1-[(S)-2-(diphenylphosphine)ferrocenyl]ethylamine. The method has the advantages that the operation