Application of E3 ubiquitinligating enzyme TRIM32 for preparing drugs for treating fatty liver and related diseases

• Main Author: LI HONGLIANG
• Format: Patent
• Language: Chinese; English
• Published: 28.08.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses application of E3 ubiquitinligating enzyme TRIM32 for preparing drugs for treating fatty liver and related diseases. A human normal liver cell L01 cell line and a TRIM32 overexpression L02 cell line are adopted as experimental subjects, and the function of the TRIM32 gene is researched through a fatty liver cell model inducted by palmitic acid and oleic acid. A result showsthat under the stimulus of palmitic acid and oleic acid, the area of red fat droplets of TRIM32 overexpression L02 cells is remarkably increased compared with a control group, and it indicates that TRIM32 overexpression can worsen lipid accumulation generated by combined induction of palmitic acid and oleic acid; in other words, the TRIM2 gene can promote development and progression of the fattyliver and related diseases. Accordingly, TRIM32 provides a target for preparing drugs for preventing, relieving and/or treating the fatty liver and related diseases. 本发明公开了E3泛素连接酶TRIM32在制备治疗脂肪肝及相关疾病药物中的应用。本发明以人正常肝细胞L02细胞系、TRIM