Tetracyclic bromodomain inhibitors

• Main Authors: JOHN PRATT, LISA A. HASVOLD, STEVEN D. FIDANZE, JUSTIN D. DIETRICH, JAMES H. HOLMS, YUJIA DAI, DAUCHUN LIU, JASMINA MARJANOVIC, LE WANG, ROBERT A. MANTEI, KEITH F. MCDANIEL, GEORGE S. SHEPPARD, ANDREW BOGDAN
• Format: Patent
• Language: Chinese; English
• Published: 24.08.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides for compounds of formula (I) wherein R1, R2, R6, Y1, Y2, Y3, A1, A2, A3 and A4 have any of the values defined in the specification, and pharmaceutically acceptable saltsthereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising one or morecompounds of formula (I). 本发明涉及四环布罗莫结构域抑制剂。本发明提供了式(I)化合物：其中R、R、R、Y、Y、Y、A、A、A和A具有任何在本说明书中定义的值，及其药学可接受的盐，其可用作疾病和疾病包括炎性疾病、癌症和AIDS的治疗中的药剂。还提供了包括种或多种式(I)化合物的药物组合物。