Pharmaceutical composition for treating myelodysplastic syndrome and preparation method thereof

• Main Authors: WAN YINGCHUN, ZHU LUJING
• Format: Patent
• Language: Chinese; English
• Published: 17.08.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to the field of pharmaceutic preparations, and particularly discloses a pharmaceutical composition for treating myelodysplastic syndrome and a preparation method thereof. The composition comprises lenalidomide, ethyl oleate, fumed silica and polyethylene glycol oleate. The selection of the adjuvant materials is capable of reducing hot-melting extrusion temperature, simplifying the extrusion process and obtaining enough strength of screw shearing action; meanwhile, a solubilization action can be realized, the hot-melting temperature can be reduced to 120 to 140 DEG C, notonly is the energy consumption reduced, but the drug stability is ensured and the dissolution rate is improved. The preparation process is simple, the energy consumption is low, no residual solvent exist and the continuous mass production is facilitated. 本发明涉及药物制剂领域，具体公开了种治疗骨髓增生异常综合症药物组合物及其制备方法。该组合物包含来那度胺、十八烯酸乙酯、气相二氧化硅、油酸聚乙二醇甘油酯。上述辅料的选择降低热熔挤出温度，易化挤出工艺，又可获得足够强度的螺杆剪切作用；同时，还能起到增溶作用，可以将热熔温度降低至120-140℃，不但降低了能耗，而且保证了药物的稳定性，提高溶出