IMPROVED CELL LINES AND USE IN ENCAPSULATED CELL BIODELIVERY

• Main Authors: KUSK PHILIP, WAHLBERG LARS ULRIK
• Format: Patent
• Language: Chinese; English
• Published: 10.08.2018
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present invention relates to a capsule for delivery of a secreted biologically active compound to a subject; cell lines expressing recombinant proteins, and generation of the cell lines for use innaked and encapsulated cell biodelivery of secreted therapeutic molecules. The invention also relates to a method for generating recombinant proteins using the cell lines. In one embodiment, the cellline is human. In another aspect of the invention, a transposon system is used for generating a cell line for secretion of a biologically active polypeptide. 本发明涉及用于向受试者递送分泌性生物活性化合物的胶囊；表达重组蛋白的细胞系；以及所述细胞系的产生，所述细胞系用于分泌性治疗分子的裸细胞生物递送和胶囊化细胞生物递送。本发明还涉及利用所述细胞系产生重组蛋白的方法。在个实施方案中，细胞系是人的细胞系。在本发明的另方面中，转座子系统用于产生用于生物活性多肽分泌的细胞系。