BIRD FLU VACCINE COMBINATION COMPRISING VIRUS-LIKE PARTICLES AND NOVEL ADJUVANTS

• Main Authors: YANG YUIH, LIANG SHU-MEI, HSIAO PEI-WEN, CHENG MINGU
• Format: Patent
• Language: Chinese; English
• Published: 03.08.2018
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

A vaccine composition is disclosed. The vaccine composition comprises: (a) a therapeutically effective amount of an influenza virus-like particle (VLP) comprising: (i) influenza M1, influenza M2, influenza hemagglutinin (HA), and influenza neuraminidase (NA) proteins; (b) Foot-and-mouth disease virus (FMDV) capsid protein VP3, recombinant FMDV VP3 (rVP3), VP3 peptide, or SUMO VP3; and (c) alum. Also disclosed is use of a vaccine composition according to the invention in the manufacture of a medicament for inducing an immunogenic response in a subject in need thereof. 本发明揭露种疫苗组合物。该疫苗组合物包含：(a)治疗有效量的流感病毒的类病毒颗粒(VLP)，其包含：流感病毒M1蛋白、流感病毒M2蛋白、流感病毒血凝素(HA)，以及流感病毒神经氨酸酶(NA)蛋白；(b)口蹄疫病毒(FMDV)VP3壳蛋白、FMDV重组VP3壳蛋白(rVP3)、VP3壳蛋白肽或SUMO VP3壳蛋白；以及(c)铝胶。本发明还揭露了根据本发明的疫苗组合物在制备用于在有此需要的受试者中诱导免疫原性反应的药物中的用途。