METHODS FOR DETECTING GENE DYSREGULATIONS

• Main Authors: SANDERS HEATHER R, ALBITAR MAHER, MELONI-EHRIG AURELIA
• Format: Patent
• Language: Chinese; English
• Published: 03.08.2018
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; VINEGAR; WINE

The subject of the invention is a method for detecting gene dysregulations. Described herein are methods, compositions and kits directed to the detection of gene dysregulations such as those arising from gene fusions and/or chromosomal abnormalities, e.g. translocations, insertions, inversions and deletions. Samples containing dysregulated gene(s) of interest may show independent expression patterns for the 5 and 3 regions of the gene. The methods, compositions and kits are useful for detecting mutations that cause the differential expression of a 5 portion of a target gene relative to the 3 region of the target gene. 本发明的发明名称是基因失调的检测方法。本文描述了涉及检测基因融合和/或染色体异常，例如易位、插入、倒位和缺失的方法、组合物和试剂盒。含有感兴趣基因的融合或基因异常的样品可以显示所述基因5'和3'区域的独立表达图式。所述方法、组合物和试剂盒对于检测导致目标基因5'部分相对于所述目标基因3'区域差异表达的突变是有用的。