COMPOSITION, CONTAINING LITHOSPERMI RADIX EXTRACT AS ACTIVE INGREDIENT, FOR PREVENTING, ALLEVIATING, OR TREATING PERIPHERAL NEUROPATHY

• Main Authors: YI JIN-MU, KIM NO-SOO, LIM CHAE-JUN, PARK JONG-SHIK, BANG OK-SUN, LEE YOU-JIN, KIM JIN-HEE, CHO EUN-SANG, KIM YOUNG-AH
• Format: Patent
• Language: Chinese; English
• Published: 31.07.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to a composition, containing a Lithospermi Radix extract as an active ingredient, for preventing, alleviating, or treating peripheral neuropathy, especially, chemotherapy-induced peripheral neuropathy (CIPN). Specifically, it was verified that the Lithospermi Radix extract of the present invention causes no toxicity in normal cells, does not influence an intrinsic cytotoxic effect of an anticancer drug in a human cancer cell line, mitigates the inhibition of neurite growth due to an anticancer drug, and effectively reduces the sensitivity to increased pain stimulation in a chemotherapy-induced peripheral neuropathy animal model, and thus the Lithospermi Radix extract can be favorably used as an active ingredient of the composition for preventing, alleviating,or treating chemotherapy-induced peripheral neuropathy. 本发明涉及用于预防、改善或治疗周围神经病变(peripheral neuropathy)，尤其由抗癌剂诱发的周围神经病变(chemotherapy-induced peripheral neuropathy，CIPN)的组合物，其含有紫草根(Lithospermi Radix)提取物作为有效成分，具体而言，确认到本发明的紫草根提取物不会