Process for the preparation of a chiral compound

The present invention relates to a process for the preparation of a compound of formula (V), in particular posaconazole, wherein said process comprises the steps of (1) providing a mixture comprisinga compound of formula (IV), a protic solvent system, and a suitable base; and (2) heating the mixture...

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Bibliographic Details
Main Authors LANGNER MARTIN, WILHELM THORSTEN
Format Patent
LanguageChinese
English
Published 27.07.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to a process for the preparation of a compound of formula (V), in particular posaconazole, wherein said process comprises the steps of (1) providing a mixture comprisinga compound of formula (IV), a protic solvent system, and a suitable base; and (2) heating the mixture of (1) to obtain a mixture comprising the compound of formula (V). 本发明涉及种制备式(V)化合物，尤其是泊沙康唑的方法，其中所述方法包括如下步骤：(1)提供包含式(IV)化合物、质子性溶剂体系和合适碱的混合物；以及(2)将(1)的混合物加热而得到包含式(V)化合物的混合物。
Bibliography:Application Number: CN201810106380