Medicine for treating pancreatitis, and preparation method thereof

• Main Authors: YANG WENPING, LIU SHUANG, JIANG HONGCHUN, HAO LINNA, SONG XIANDONG, SONG XIANXU, LI HONGHAI, WU YAN, WANG MEI, ZHU MIN
• Format: Patent
• Language: Chinese; English
• Published: 20.07.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a new pyrimido-oxazine compound. With the compound, the increment of amylase-lipase activity of sera of rats with acute pancreatitis can be remarkably inhibited, and the watercontent of pancreatic tissues of the rats with acute pancreatitis can be remarkably reduced, so that the compound has a favorable treatment effect on acute pancreatitis. In addition, compared with anexisting medicine gabexate, the treatment effect is more remarkable. 本发明涉及种新的嘧啶并嗪类化合物，所述化合物能够显著抑制急性胰腺炎大鼠血清的淀粉酶和脂肪酶活性的增加，能够明显减少急性胰腺炎大鼠胰腺组织的含水量，因此对于急性胰腺炎具有良好的治疗作用。而且与已有药物加贝酯相比，所述治疗作用更加显著。